The brain’s response to alcohol varies based on individual preferences, according to new research in rats published in eNeuro.

Not everyone is prone to developing an alcohol use disorder. Some people can drink every day without acquiring a dependence, yet far less drinking may drive another person into addiction. This difference may be explained by how the brain interprets alcohol as a reward. The orbitofrontal cortex (OFC) stores reward value and regulates reward seeking, so OFC activity corresponds to individual preferences for drugs. Its malfunctioning may be involved in drug use disorders.

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