Olfactory sensory neurons are nasal neurons that make use of hundreds of different types of odorant receptors to analyze odorous chemicals in our external world and send that information to our brain. These neurons have the unusual ability to undergo turnover throughout life—a process understood to happen due to the special vulnerability of these neurons to environmental insults, such as viruses.

The paper, out today from the University of Colorado Anschutz Medical Campus and published in Cell Reports, explores whether this process has a function beyond just replacement. After lessening odors though one side of the nose, researchers examined the birth rates of different subtypes of olfactory sensory neurons in mice to determine how odor stimulation can affect the regeneration process. Results show that diminished odor stimulation reduces the number of newly-generated neurons that express particular odorant receptors, indicating a selective alteration in the neurogenesis of these neuron subtypes.

“This is surprising because when a new neuron is born, the receptor that it chooses, and thus its subtype, is thought to be random” said Stephen Santoro, Ph.D., University of Colorado School of Medicine assistant professor and lead author. “Our results show that the birth of some neurons depends on odor stimulation. These findings challenge the current model that the subtype identities of new neurons are random. We think this paper provides evidence that what is currently understood about how olfactory sensory neurons develop is incomplete. It also provides hints that life-long olfactory sensory neurogenesis may have an important adaptive function in addition to simple repair.”

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