Involvement of brain peptide dynamics in the pathology of fatty liver disease

MASLD is a disease that causes complications in various organs in the body; however, its exact etiology is unclear and there is no definitive treatment
We have determined that the autonomic neural pathway that connects the liver, brain, and intestines is involved in the onset and progression of MASLD.
We have discovered that Ghrelin secreted from the stomach activates the growth hormone (GH) release from the pituitary gland through neural signal transduction, and growth hormone in the bloodstream induces insulin-like growth factor 1 (IGF-1) secretion from the hepatocytes, which suppresses the MASLD progression.
We revealed that brain peptides activate GH–IGF-1 axis to prevent the progression of the early stages of MASLD pathology.