Involvement of brain peptide dynamics in the pathology of fatty liver disease

Involvement of Brain Peptide Dynamics in the Pathology of Fatty Liver Disease | News

  • MASLD is a disease that causes complications in various organs in the body; however, its exact etiology is unclear and there is no definitive treatment
  • We have determined that the autonomic neural pathway that connects the liver, brain, and intestines is involved in the onset and progression of MASLD.
  • We have discovered that Ghrelin secreted from the stomach activates the growth hormone (GH) release from the pituitary gland through neural signal transduction, and growth hormone in the bloodstream induces insulin-like growth factor 1 (IGF-1) secretion from the hepatocytes, which suppresses the MASLD progression.
  • We revealed that brain peptides activate GH–IGF-1 axis to prevent the progression of the early stages of MASLD pathology.

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